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p-Fluoro-L-phenylalanine

  • CAS No. 1132-68-9

  • Cat. No. CS-W002291
  • Purity≥96%
  • MDL No.MFCD00063064

*For research and further manufacturing use only, not for direct human use.

p-Fluoro-L-phenylalanine|CS-W002291

Structure of 1132-68-9

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General Information

  • CAS No. 1132-68-9
  • Cat. No. CS-W002291
  • Purity ≥96%
  • MDL No. MFCD00063064
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₀FNO₂
  • Molecular Weight 183.18
  • Synonym(s) 4-Fluoro-L-phenylalanine
  • SMILES O=C(O)[C@H](CC1=CC=C(F)C=C1)N

Description

p-Fluoro-L-phenylalanine integrates a fluorine atom at the para position of the aromatic ring, enhancing metabolic stability and bioavailability in peptide synthesis. This bench-stable derivative serves as a structural analog for L-phenylalanine, enabling site-specific incorporation into therapeutic peptides to modulate pharmacokinetics and improve target engagement.

Synthesis

  • Route1

    References

    • Gloge, Andreas; Zon, Jerzy; Koevari, Agnes; Poppe, Laszlo; Retey, Janos Chemistry - A European Journal, 2000 , vol. 6, # 18 p. 3386 - 3390
  • Route2
    • null|null
      133919-66-1
    • ~99%
    • In-stock
      p-Fluoro-L-phenylalanine|CS-W002291
      1132-68-9

    References

    • Yasukawa, Kazuyuki; Asano, Yasuhisa Advanced Synthesis and Catalysis, 2012 , vol. 354, # 17 p. 3327 - 3332
  • Route3

    References

    • Asano; Yamada; Kato; Yamaguchi; Hibino; Hirai; Kondo Journal of Organic Chemistry, 1990 , vol. 55, # 21 p. 5567 - 5571

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   63.32
  • LogP   0.7801
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   3

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