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CS-W001157 4
Total: USD 88.00

6-Fluoroquinaldine

  • CAS No. 1128-61-6

  • Cat. No. CS-W008815
  • Purity≥97%
  • MDL No.MFCD00041233

*For research and further manufacturing use only, not for direct human use.

6-Fluoroquinaldine|CS-W008815

Structure of 1128-61-6

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General Information

  • CAS No. 1128-61-6
  • Cat. No. CS-W008815
  • Purity ≥97%
  • MDL No. MFCD00041233
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₈FN
  • Molecular Weight 161.18
  • Synonym(s) 6-Fluoro-2-methylquinoline; 2-Methyl-6-fluoroquinoline; 6-Fluoro-2-methyl-1-azanaphthalene
  • SMILES CC1=NC2=CC=C(F)C=C2C=C1

Description

6-Fluoroquinaldine features a fluorinated quinoline core with enhanced electron-withdrawing character, enabling efficient coupling in palladium-catalyzed cross-coupling reactions. This bench-stable heteroaryl aldehyde integrates readily into complex molecular architectures, particularly in medicinal chemistry and materials science applications.

Synthesis

  • Route1

    References

    • Lee, Hong Geun; Milner, Phillip J.; Buchwald, Stephen L. Journal of the American Chemical Society, 2014 , vol. 136, # 10 p. 3792 - 3795
  • Route2
    • (R)-6-Fluoro-2-methyl-1,2,3,4-tetrahydroquinoline|CS-0721280
      199186-69-1
    • ~%
    • In-stock
      6-Fluoroquinaldine|CS-W008815
      1128-61-6

    References

    • Tetrahedron Asymmetry, , vol. 12, # 24 p. 3435 - 3439
  • Route3
    • null|null
      1253423-94-7
    • ~79%
    • In-stock
      6-Fluoroquinaldine|CS-W008815
      1128-61-6

    References

    • Ramesh, Chintakunta; Kavala, Veerababurao; Kuo, Chun-Wei; Yao, Ching-Fa Tetrahedron Letters, 2010 , vol. 51, # 40 p. 5234 - 5237

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H315-H318
Precautionary Statements : P264-P280-P302+P352-P362+P364

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.68232
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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