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Structure of 1127-85-1
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This tetrahydroquinazoline scaffold delivers a rigid, electron-deficient core ideal for medicinal chemistry applications. The 2,4-dichloro substitution pattern enhances metabolic stability and modulates target affinity, while the saturated ring system improves solubility and bioavailability. This compound serves as a key intermediate in the synthesis of kinase inhibitors and other bioactive heterocycles.
2,4-Dichloro-5,6,7,8-tetrahydroquinazoline serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to quinazoline-based scaffolds. Its dichloro substitution pattern facilitates directed functionalization and enhances metabolic stability in target molecules. The tetrahydro core offers improved solubility and handling compared to fully aromatic analogs, while maintaining reactivity for downstream coupling processes. This compound functions reliably in standard synthetic workflows, supporting scalable synthesis of kinase inhibitors and other bioactive compounds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: