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CS-W001157 4
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2-Bromo-6-(methoxymethyl)pyridine

  • CAS No. 112575-15-2

  • Cat. No. CS-0192967
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Bromo-6-(methoxymethyl)pyridine|CS-0192967

Structure of 112575-15-2

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General Information

  • CAS No. 112575-15-2
  • Cat. No. CS-0192967
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈BrNO
  • Molecular Weight 202.05
  • Synonym(s) 2-bromo-6-methoxymethyl-pyridine
  • SMILES COCC1=CC=CC(Br)=N1

Description

2-Bromo-6-(methoxymethyl)pyridine features a bromine atom at the 2-position and a methoxymethyl group at the 6-position of the pyridine ring, offering enhanced reactivity and solubility in polar solvents. This configuration enables efficient coupling reactions in synthetic pathways, particularly in transition metal-catalyzed transformations. The compound exhibits bench-stable handling under standard conditions and serves as a valuable building block for pharmaceutical intermediates and functionalized heterocycles.

Application

2-Bromo-6-(methoxymethyl)pyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its well-defined electrophilic bromide and stable methoxymethyl side chain. The pyridine core provides excellent functional group tolerance, while the methoxymethyl group offers orthogonal protection potential. This compound facilitates efficient construction of complex heterocyclic scaffolds and is valued for its bench stability and ease of purification in multi-step syntheses.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   22.12
  • LogP   1.9905
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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