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CS-W001157 4
Total: USD 88.00

4-Nitropyridine

  • CAS No. 1122-61-8

  • Cat. No. CS-0059175
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Nitropyridine|CS-0059175

Structure of 1122-61-8

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General Information

  • CAS No. 1122-61-8
  • Cat. No. CS-0059175
  • Purity ≥96%
  • MDL No. None
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄N₂O₂
  • Molecular Weight 124.10
  • Synonym(s) IFLAB-BB F1371-0143
  • SMILES O=[N+](C1=CC=NC=C1)[O-]

Description

4-Nitropyridine features a para-nitro group on a pyridine ring, delivering strong electron-withdrawing character essential for nucleophilic substitution reactions. This bench-stable compound serves as a key scaffold in medicinal chemistry and materials science, enabling efficient functionalization under standard conditions.

Application

4-Nitropyridine serves as a versatile building block in synthetic organic chemistry, enabling direct functionalization at the pyridine ring due to its electron-deficient nature. It functions as a key intermediate in the construction of heterocyclic scaffolds and facilitates nucleophilic substitution reactions under mild conditions. Its bench stability and compatibility with diverse reaction partners make it well-suited for applications in medicinal chemistry and process development.

Synthesis

  • Route1
    • null|null
      1124-33-0
    • ~98%
    • In-stock
      4-Nitropyridine|CS-0059175
      1122-61-8

    References

    • Wang, Ying; Espenson, James H. Organic Letters, 2000 , vol. 2, # 22 p. 3525 - 3526
  • Route2
    • null|null
      54750-97-9
    • ~56%
    • In-stock
      4-Nitropyridine|CS-0059175
      1122-61-8

    References

    • Tani; Lukin; Eaton Journal of the American Chemical Society, 1997 , vol. 119, # 6 p. 1476 - 1477
  • Route3
    • null|null
      1124-33-0
    • ~4%
    • In-stock
      4-Nitropyridine|CS-0059175
      1122-61-8
    • null|null
      50-00-0
    • null|null
      100-61-8

    References

    • Sako, Magoichi; Shimada, Kaoru; Hirota, Kosaku; Maki, Yoshifumi Journal of the American Chemical Society, 1986 , vol. 108, # 19 p. 6039 - 6041

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   56.03
  • LogP   0.9898
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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