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CS-W001157 4
Total: USD 88.00

4,6-Dimethoxypyrimidin-5-methylamine

  • CAS No. 1118786-90-5

  • Cat. No. CS-0186926
  • Purity≥95%
  • MDL No.None
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

4,6-Dimethoxypyrimidin-5-methylamine|CS-0186926

Structure of 1118786-90-5

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Description

4,6-Dimethoxypyrimidin-5-methylamine features a pyrimidine core bearing methoxy groups at positions 4 and 6, enhancing solubility and metabolic stability. The methylamine substituent at C5 provides a reactive handle for conjugation, enabling efficient incorporation into bioactive scaffolds. This compound serves as a key building block in medicinal chemistry, particularly for kinase inhibitors and antiviral agents.

Application

4,6-Dimethoxypyrimidin-5-methylamine serves as a versatile building block in medicinal chemistry, enabling efficient access to pyrimidine-based scaffolds. Its ortho-dimethoxy functionality enhances stability and facilitates regioselective functionalization, while the methylamine group offers direct coupling potential. The compound exhibits excellent bench stability and compatibility with standard amine protection and cross-coupling protocols, making it well-suited for modular synthesis of kinase inhibitors and other bioactive heterocycles.

General Information

  • CAS No. 1118786-90-5
  • Cat. No. CS-0186926
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₁N₃O₂
  • Molecular Weight 169.18
  • Synonym(s) (4,6-Dimethoxypyrimidin-5-yl)methanamine
  • SMILES COC1=C(CN)C(=NC=N1)OC

Computational Chemistry Data

  • TPSA   70.26
  • LogP   -0.0475
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   3

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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