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5-[(3,5-Difluorophenyl)methyl]-1H-indazol-3-amine

  • CAS No. 1108745-30-7

  • Cat. No. CS-0056813
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-[(3,5-Difluorophenyl)methyl]-1H-indazol-3-amine|CS-0056813

Structure of 1108745-30-7

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General Information

  • CAS No. 1108745-30-7
  • Cat. No. CS-0056813
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₁F₂N₃
  • Molecular Weight 259.25
  • Synonym(s) 5-(3,5-difluoro-benzyl)-1H-indazol-3-ylamine
  • SMILES NC1=NNC2=C1C=C(CC3=CC(F)=CC(F)=C3)C=C2

Description

This indazolamine features a 3,5-difluorophenylmethyl substituent that enhances electron-withdrawing character and metabolic stability. The pendant amine group enables facile derivatization, while the fused heterocyclic core provides rigidity for target engagement in kinase inhibition studies.

Application

5-[(3,5-Difluorophenyl)methyl]-1H-indazol-3-amine serves as a versatile building block for medicinal chemistry campaigns, enabling rapid access to bioactive heterocycles. The indazol-3-amine core facilitates palladium-catalyzed coupling reactions, while the 3,5-difluorophenylmethyl group provides enhanced metabolic stability and favorable lipophilicity. Bench-stable and compatible with standard purification methods, it functions effectively in multi-step syntheses of kinase inhibitors and CNS-targeted compounds.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   54.7
  • LogP   3.0141
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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