5-Cyano-2-fluorobenzene-1-sulfonyl chloride

Name: 5-Cyano-2-fluorobenzene-1-sulfonyl chloride
Brand: ChemScene
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CAS No. 1101120-80-2
Cat. No. CS-W018713
Purity≥98%
MDL No.MFCD18394026

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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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5-Cyano-2-fluorobenzene-1-sulfonyl chloride|CS-W018713

Structure of 1101120-80-2

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Description

5-Cyano-2-fluorobenzene-1-sulfonyl chloride features a fluorinated aromatic ring paired with electron-withdrawing cyano and sulfonyl chloride groups, enabling selective electrophilic functionalization. This combination imparts high reactivity in amide and sulfonamide synthesis while maintaining stability under standard bench conditions.

Application

5-Cyano-2-fluorobenzene-1-sulfonyl chloride serves as a versatile building block for the synthesis of sulfonamide-containing heterocycles and bioactive molecules. Its reactivity is enhanced by the electron-withdrawing cyano and fluorine substituents, which stabilize the sulfonyl chloride moiety and facilitate nucleophilic substitution under mild conditions. The compound exhibits excellent bench stability and compatibility with diverse functional groups, enabling efficient incorporation into pharmaceutical intermediates and agrochemical scaffolds via standard amine coupling protocols.

General Information

CAS No. 1101120-80-2
Cat. No. CS-W018713
Purity ≥98%
MDL No. MFCD18394026
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₃ClFNO₂S
Molecular Weight 219.62
Synonym(s) 5-Cyano-2-fluorobenzenesulfonyl chloride
SMILES O=S(C1=CC(C#N)=CC=C1F)(Cl)=O

Computational Chemistry Data

TPSA 57.93
LogP 1.62488
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 3261
Class : 8	Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Other Classifications

Building Blocks Functional Group Sulfonyl Chloride

Building Blocks Functional Group Cyanide/Nitrile

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

1101120-80-2 sigma1101120-80-2 manufacturer1101120-80-2 price1101120-80-2 structure1101120-80-2 SDSbuy 1101120-80-21101120-80-2 supplier1101120-80-2 uses1101120-80-2 molecular weightprice of 1101120-80-21101120-80-2 chemical name formula of 1101120-80-2

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5-Cyano-2-fluorobenzene-1-sulfonyl chloride

CAS No. 1101120-80-2

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