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CS-W001157 4
Total: USD 88.00

(5-Bromo-2-chlorophenyl)methanamine

  • CAS No. 1096296-85-3

  • Cat. No. CS-W018842
  • Purity≥97%
  • MDL No.MFCD12026286

*For research and further manufacturing use only, not for direct human use.

(5-Bromo-2-chlorophenyl)methanamine|CS-W018842

Structure of 1096296-85-3

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General Information

  • CAS No. 1096296-85-3
  • Cat. No. CS-W018842
  • Purity ≥97%
  • MDL No. MFCD12026286
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇BrClN
  • Molecular Weight 220.49
  • Synonym(s) 5-Bromo-2-chlorobenzylamine
  • SMILES NCC1=CC(Br)=CC=C1Cl

Description

(5-Bromo-2-chlorophenyl)methanamine is a halogenated aromatic amine featuring complementary bromo and chloro substituents at meta and ortho positions, respectively. This configuration imparts enhanced electronic tuning and steric definition, enabling precise integration into pharmaceutical intermediates and functionalized building blocks for medicinal chemistry applications.

Application

(5-Bromo-2-chlorophenyl)methanamine serves as a versatile building block for the synthesis of biologically active compounds, leveraging its ortho-halogenated aryl scaffold. The amine functionality enables direct coupling reactions, while the bromo and chloro groups facilitate subsequent cross-coupling or electrophilic substitution processes. Its bench-stable nature and compatibility with standard purification methods make it suitable for iterative synthetic workflows in medicinal chemistry and process development.

Synthesis

  • Route1
    • null|null
      478374-91-3
    • ~67%
    • In-stock
      (5-Bromo-2-chlorophenyl)methanamine|CS-W018842
      1096296-85-3

    References

    • PHARMACOPEIA, INC. Patent: WO2009/62059 A2, 2009 ; Location in patent: Page/Page column 39-40 ; WO 2009/062059 A2
  • Route2
    • null|null
      251085-86-6
    • ~%
    • In-stock
      (5-Bromo-2-chlorophenyl)methanamine|CS-W018842
      1096296-85-3

    References

    • WO2011/59619 A1, ; Page/Page column 39 ;
  • Route3

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 14 p. 4060 - 4064

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.5612
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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