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CS-W001157 4
Total: USD 88.00

Methyl 1-Boc-5-hydroxypiperidine-3-carboxylate

  • CAS No. 1095010-47-1

  • Cat. No. CS-W001295
  • Purity≥97%
  • MDL No.MFCD11656770

*For research and further manufacturing use only, not for direct human use.

Methyl 1-Boc-5-hydroxypiperidine-3-carboxylate|CS-W001295

Structure of 1095010-47-1

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General Information

  • CAS No. 1095010-47-1
  • Cat. No. CS-W001295
  • Purity ≥97%
  • MDL No. MFCD11656770
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₂₁NO₅
  • Molecular Weight 259.30
  • Synonym(s) 1,3-Piperidinedicarboxylic acid, 5-hydroxy-, 1-(1,1-dimethylethyl) 3-methyl ester
  • SMILES COC(=O)C1CC(O)CN(C1)C(=O)OC(C)(C)C

Description

Methyl 1-Boc-5-hydroxypiperidine-3-carboxylate features a bench-stable Boc-protected piperidine core with a pendant hydroxyl group at the 5-position and a methyl ester at the 3-position. This bifunctional scaffold enables direct incorporation into complex heterocyclic frameworks, offering orthogonal reactivity for peptide coupling and downstream derivatization in medicinal chemistry campaigns.

Application

Methyl 1-Boc-5-hydroxypiperidine-3-carboxylate serves as a versatile building block for the synthesis of bioactive heterocycles and peptidomimetics. The Boc-protected amine enables orthogonal functionalization, while the pendant hydroxyl group facilitates selective derivatization. Its stability under standard reaction conditions and ease of purification make it ideal for iterative synthetic sequences in medicinal chemistry and process development.

Synthesis

  • Route1
    • In-stock
      Di-tert-butyl dicarbonate|CS-0017817
      24424-99-5
    • Methyl 5-hydroxypiperidine-3-carboxylate|CS-0440767
      1095010-44-8
    • ~%
    • In-stock
      Methyl 1-Boc-5-hydroxypiperidine-3-carboxylate|CS-W001295
      1095010-47-1

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 10 p. 3095 - 3098
  • Route2

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 10 p. 3095 - 3098
  • Route3

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 10 p. 3095 - 3098

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   76.07
  • LogP   0.7773
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   1

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