6-Chloro-2-fluoronicotinaldehyde

Name: 6-Chloro-2-fluoronicotinaldehyde
Brand: ChemScene
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CAS No. 1093880-37-5
Cat. No. CS-0036103
Purity≥98%
MDL No.MFCD16556251

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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6-Chloro-2-fluoronicotinaldehyde|CS-0036103

Structure of 1093880-37-5

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General Information

CAS No. 1093880-37-5
Cat. No. CS-0036103
Purity ≥98%
MDL No. MFCD16556251
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₃ClFNO
Molecular Weight 159.55
Synonym(s) 6-Chloro-2-fluoropyridine-3-carboxaldehyde
SMILES C1=C(C=O)C(=NC(=C1)Cl)F

Description

6-Chloro-2-fluoronicotinaldehyde features a highly reactive aldehyde group flanked by electron-withdrawing chlorine and fluorine substituents, enhancing electrophilicity for nucleophilic addition. This bench-stable heterocyclic scaffold integrates readily into synthetic routes requiring polarized carbonyl functionality, particularly in medicinal chemistry and agrochemical development.

Application

6-Chloro-2-fluoronicotinaldehyde serves as a versatile building block in medicinal chemistry, enabling the synthesis of fluorinated heterocycles and bioactive scaffolds. Its ortho-fluoro and meta-chloro substituents enhance electrophilicity at the aldehyde position, facilitating efficient nucleophilic additions and condensation reactions. The compound exhibits good bench stability and is compatible with standard purification protocols, making it well-suited for iterative synthetic workflows in API development.

Synthesis

Route1
- In-stock
  
  20885-12-5
- 68-12-2
- ~88%
- In-stock
  
  1093880-37-5
References
- BRANDEIS UNIVERSITY; SNIDER, Barry; ZHOU, Quan Patent: WO2012/78608 A1, 2012 ; Location in patent: Page/Page column 30-31 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 29.96
LogP 1.6866
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Aldehyde

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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6-Chloro-2-fluoronicotinaldehyde

CAS No. 1093880-37-5

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