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CS-W001157 4
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(1H-Indazol-7-yl)methanol

  • CAS No. 1092961-09-5

  • Cat. No. CS-0052541
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(1H-Indazol-7-yl)methanol|CS-0052541

Structure of 1092961-09-5

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General Information

  • CAS No. 1092961-09-5
  • Cat. No. CS-0052541
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈N₂O
  • Molecular Weight 148.16
  • Synonym(s) 7-Hydroxymethyl-1H-indazole
  • SMILES OCC1=C2NN=CC2=CC=C1

Description

(1H-Indazol-7-yl)methanol features a rigid indazole core with a primary alcohol handle at the 7-position, enabling direct functionalization in synthetic workflows. This bench-stable scaffold integrates readily into bioactive molecule design, offering enhanced solubility and metabolic stability compared to parent heterocycles.

Application

(1H-Indazol-7-yl)methanol serves as a versatile building block for the synthesis of indazolyl-containing pharmaceuticals and functional materials. Its benzylic alcohol functionality enables straightforward derivatization via oxidation, etherification, or esterification, while the indazole core offers robust metabolic stability and favorable binding interactions in medicinal chemistry applications. The compound exhibits good bench stability and is readily purified by standard chromatographic methods, facilitating integration into multi-step synthetic sequences.

Synthesis

  • Route1

    References

    • Journal of Medicinal Chemistry, , vol. 56, # 4 p. 1677 - 1692

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   48.91
  • LogP   1.0552
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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