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CS-W001157 4
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3-Chloro-N,N-dimethylpropan-1-amine

  • CAS No. 109-54-6

  • Cat. No. CS-W004690
  • Purity≥98%
  • MDL No.MFCD00044496

*For research and further manufacturing use only, not for direct human use.

3-Chloro-N,N-dimethylpropan-1-amine|CS-W004690

Structure of 109-54-6

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General Information

  • CAS No. 109-54-6
  • Cat. No. CS-W004690
  • Purity ≥98%
  • MDL No. MFCD00044496
  • Storage -20°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₂ClN
  • Molecular Weight 121.61
  • Synonym(s) N-(3-chloropropyl)dimethylamine
  • SMILES CN(C)CCCCl

Description

This chloroamine derivative features a reactive chloride at the β-position, enabling efficient alkylation under mild conditions. The dimethylamino group enhances nucleophilicity and solubility in polar solvents, facilitating use in synthetic transformations requiring stable, bench-ready amine equivalents.

Application

3-Chloro-N,N-dimethylpropan-1-amine serves as a versatile bifunctional building block in synthetic organic chemistry, enabling efficient construction of nitrogen-containing heterocycles and medicinal intermediates. The chloro group facilitates nucleophilic substitution reactions, while the tertiary amine functions as a directing group or protonation site. Its bench-stable nature and compatibility with diverse reaction conditions make it well-suited for modular synthesis workflows in API development and medicinal chemistry.

Synthesis

  • Route1

    References

    • WO2007/54105 A2, ; Page/Page column 20 ;
  • Route2
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      124-40-3
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      109-70-6
    • ~%
    • In-stock
      3-Chloro-N,N-dimethylpropan-1-amine|CS-W004690
      109-54-6

    References

    • CH221596 , ; Helv.Engi-Festschr., <1941>215
  • Route3
    • null|null
      3179-63-3
    • ~%
    • In-stock
      3-Chloro-N,N-dimethylpropan-1-amine|CS-W004690
      109-54-6

    References

    • Annales Pharmaceutiques Francaises, , vol. 4, p. 173 Chem.Abstr., , p. 5099

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   3.24
  • LogP   1.1769
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   3

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