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CS-W001157 4
Total: USD 88.00

(6-(Methylsulfonyl)pyridin-3-yl)boronic acid

  • CAS No. 1088496-41-6

  • Cat. No. CS-0053964
  • Molecule weight201.01
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(6-(Methylsulfonyl)pyridin-3-yl)boronic acid|CS-0053964

Structure of 1088496-41-6

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General Information

  • CAS No. 1088496-41-6
  • Cat. No. CS-0053964
  • Purity ≥95%
  • MDL No. None
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₈BNO₄S
  • Molecular Weight 201.01
  • Synonym(s) 2-(Methylsulfonyl)pyridine-5-boronic acid
  • SMILES O=S(C1=CC=C(B(O)O)C=N1)(C)=O

Description

This boronate moiety integrates a methylsulfonyl group at the pyridine 6-position, enhancing solubility and stability. The electron-deficient pyridine ring enables efficient Suzuki-Miyaura coupling under mild conditions. This bench-stable reagent facilitates rapid access to functionalized heterocycles in medicinal chemistry and materials science applications.

Application

(6-(Methylsulfonyl)pyridin-3-yl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient C–C bond formation under mild conditions. The pyridine scaffold provides orthogonal reactivity and enhanced solubility, while the methylsulfonyl group enhances metabolic stability and modulates electronic properties. Bench-stable and readily purified by flash chromatography, it facilitates the construction of complex heterocyclic architectures common in pharmaceutical intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H317-H319
Precautionary Statements : P261-P264-P272-P280-P302+P352-P362+P364-P501

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Computational Chemistry Data

  • TPSA   87.49
  • LogP   -1.8351
  • H_Acceptors   5
  • H_Donors   2
  • Rotatable_Bonds   2

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