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tert-Butyl 2,6-diazaspiro[3.5]nonane-2-carboxylate

  • CAS No. 1086394-57-1

  • Cat. No. CS-0000640
  • Purity≥95%
  • MDL No.MFCD11053736

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 2,6-diazaspiro[3.5]nonane-2-carboxylate|CS-0000640

Structure of 1086394-57-1

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General Information

  • CAS No. 1086394-57-1
  • Cat. No. CS-0000640
  • Purity ≥95%
  • MDL No. MFCD11053736
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₂₂N₂O₂
  • Molecular Weight 226.32
  • Synonym(s) 2,6-Diazaspiro[3.5]nonane-2-carboxylic acid tert-butyl ester
  • SMILES O=C(OC(C)(C)C)N(C1)CC21CNCCC2

Description

tert-Butyl 2,6-diazaspiro[3.5]nonane-2-carboxylate features a rigid spirocyclic core with two nitrogen atoms at the 2- and 6-positions, offering enhanced conformational control. The tert-butyl ester group provides excellent stability and ease of deprotection under mild conditions. This scaffold serves as a privileged building block in medicinal chemistry for accessing complex heterocycles.

Application

tert-Butyl 2,6-diazaspiro[3.5]nonane-2-carboxylate serves as a versatile spirocyclic scaffold for medicinal chemistry and catalyst design, offering enhanced conformational rigidity and improved metabolic stability. The protected diamine core enables selective functionalization at both nitrogen atoms, facilitates orthogonal derivatization, and supports efficient incorporation into bioactive heterocycles. Its bench-stable, crystalline nature simplifies handling and purification, making it well-suited for modular synthesis of complex pharmaceutical intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   41.57
  • LogP   1.6069
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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