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CS-W001157 4
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6-Bromo-2-(methylsulfanyl)quinazoline

  • CAS No. 1086385-16-1

  • Cat. No. CS-0050303
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-Bromo-2-(methylsulfanyl)quinazoline|CS-0050303

Structure of 1086385-16-1

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General Information

  • CAS No. 1086385-16-1
  • Cat. No. CS-0050303
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₇BrN₂S
  • Molecular Weight 255.13
  • Synonym(s) 6-BroMo-2-(Methylthio)-quinazoline
  • SMILES CSC1=NC2=CC=C(Br)C=C2C=N1

Description

6-Bromo-2-(methylsulfanyl)quinazoline features a bromine substituent at the 6-position and a methylthio group at the 2-position on the quinazoline core. This electron-deficient scaffold enables direct functionalization in cross-coupling reactions, serving as a key building block for kinase inhibitors and advanced pharmaceutical intermediates under standard conditions.

Application

6-Bromo-2-(methylsulfanyl)quinazoline serves as a versatile building block for the synthesis of quinazoline-based pharmaceutical intermediates. The bromine at C6 enables palladium-catalyzed cross-coupling reactions, while the methylthio group at C2 offers orthogonal reactivity and facilitates further functionalization. Its bench-stable nature and compatibility with standard coupling protocols make it well-suited for medicinal chemistry campaigns requiring rapid scaffold diversification.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   3.1142
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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