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CS-W001157 4
Total: USD 88.00

3-Bromo-5-(trifluoromethyl)-1H-indazole

  • CAS No. 1086378-32-6

  • Cat. No. CS-0052540
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Bromo-5-(trifluoromethyl)-1H-indazole|CS-0052540

Structure of 1086378-32-6

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General Information

  • CAS No. 1086378-32-6
  • Cat. No. CS-0052540
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₄BrF₃N₂
  • Molecular Weight 265.03
  • Synonym(s) None
  • SMILES FC(F)(F)C1=CC2=C(NN=C2Br)C=C1

Description

3-Bromo-5-(trifluoromethyl)-1H-indazole is a fluorinated heterocyclic building block featuring a bromine atom at the 3-position and a trifluoromethyl group at the 5-position, enabling facile functionalization via cross-coupling reactions. This electron-deficient indazole derivative exhibits enhanced metabolic stability and favorable solubility in organic solvents, making it well-suited for pharmaceutical synthesis and materials science applications.

Application

3-Bromo-5-(trifluoromethyl)-1H-indazole serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its stable bromo functionality and electron-deficient indazole core. The trifluoromethyl group enhances metabolic stability and modulates lipophilicity, while the indazole scaffold provides a rigid, bioisostatic platform for kinase inhibitors and other targeted therapeutics. Its bench-stable crystalline form facilitates handling and purification in multi-step syntheses.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   28.68
  • LogP   3.3442
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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