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CS-W001157 4
Total: USD 88.00

1-Phenylpiperidin-4-amine

  • CAS No. 63921-23-3

  • Cat. No. CS-0099497
  • Purity≥97%
  • MDL No.MFCD00044398

*For research and further manufacturing use only, not for direct human use.

1-Phenylpiperidin-4-amine|CS-0099497

Structure of 63921-23-3

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General Information

  • CAS No. 63921-23-3
  • Cat. No. CS-0099497
  • Purity ≥97%
  • MDL No. MFCD00044398
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₆N₂
  • Molecular Weight 176.26
  • Synonym(s) LABOTEST-BB LTBB000705
  • SMILES NC1CCN(CC1)C2=CC=CC=C2

Description

1-Phenylpiperidin-4-amine features a conjugated phenyl ring attached to a piperidine scaffold, delivering enhanced electron density at the amine site. This structural motif enables robust engagement in receptor binding assays and serves as a key pharmacophore in CNS-targeted compound development. The molecule exhibits favorable solubility and stability under standard handling conditions.

Application

1-Phenylpiperidin-4-amine serves as a versatile scaffold in medicinal chemistry, enabling the construction of diverse heterocyclic systems through standard functionalization. Its amine functionality facilitates facile derivatization via alkylation, acylation, and reductive amination, while the piperidine ring offers favorable pharmacokinetic properties. Bench-stable and readily purified by standard techniques, it functions effectively in both small-molecule discovery and process-scale synthesis.

Synthesis

  • Route1
    • null|null
      7402-94-0
    • ~75%
    • In-stock
      1-Phenylpiperidin-4-amine|CS-0099497
      63921-23-3

    References

    • F2G LIMITED Patent: US2011/9390 A1, 2011 ; Location in patent: Page/Page column 19 ;
  • Route2
    • null|null
      19125-34-9
    • ~%
    • In-stock
      1-Phenylpiperidin-4-amine|CS-0099497
      63921-23-3

    References

    • Recueil des Travaux Chimiques des Pays-Bas, , vol. 112, # 10 p. 535 - 548
  • Route3

    References

    • Journal of the American Chemical Society, , vol. 122, # 15 p. 3721 - 3730

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.26
  • LogP   1.6141
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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