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Structure of 1086378-32-6
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3-Bromo-5-(trifluoromethyl)-1H-indazole is a fluorinated heterocyclic building block featuring a bromine atom at the 3-position and a trifluoromethyl group at the 5-position, enabling facile functionalization via cross-coupling reactions. This electron-deficient indazole derivative exhibits enhanced metabolic stability and favorable solubility in organic solvents, making it well-suited for pharmaceutical synthesis and materials science applications.
3-Bromo-5-(trifluoromethyl)-1H-indazole serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its stable bromo functionality and electron-deficient indazole core. The trifluoromethyl group enhances metabolic stability and modulates lipophilicity, while the indazole scaffold provides a rigid, bioisostatic platform for kinase inhibitors and other targeted therapeutics. Its bench-stable crystalline form facilitates handling and purification in multi-step syntheses.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: