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CS-W001157 4
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Boronic acid, B-[3-fluoro-4-(hydroxymethyl)phenyl]-

  • CAS No. 1082066-52-1

  • Cat. No. CS-0029534
  • Purity≥97%
  • MDL No.MFCD13181609

*For research and further manufacturing use only, not for direct human use.

Boronic acid, B-[3-fluoro-4-(hydroxymethyl)phenyl]-|CS-0029534

Structure of 1082066-52-1

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General Information

  • CAS No. 1082066-52-1
  • Cat. No. CS-0029534
  • Purity ≥97%
  • MDL No. MFCD13181609
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈BFO₃
  • Molecular Weight 169.95
  • Synonym(s) 3-floro-4-hydroxymethylbenzeneboronicacid
  • SMILES OCC1=CC=C(B(O)O)C=C1F

Description

This boronic acid features a fluorinated aryl ring paired with a hydroxymethyl handle, enabling efficient coupling in Suzuki-Miyaura reactions. The electron-deficient aromatic system enhances reactivity while maintaining bench-stable handling under standard conditions.

Application

(3-Fluoro-4-(hydroxymethyl)phenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient C–C bond formation under mild conditions. The ortho-fluoro substituent enhances regioselectivity and metabolic stability, while the boronic acid and hydroxymethyl groups offer orthogonal reactivity for downstream functionalization. Bench-stable and readily purified by recrystallization, it facilitates streamlined synthesis of fluorinated aryl scaffolds relevant to medicinal chemistry and materials science.

Safety Information

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Computational Chemistry Data

  • TPSA   60.69
  • LogP   -1.0022
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   2

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