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(2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol

  • CAS No. 1082066-29-2

  • Cat. No. CS-0097682
  • Purity≥97%
  • MDL No.MFCD18732617

*For research and further manufacturing use only, not for direct human use.

(2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol|CS-0097682

Structure of 1082066-29-2

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General Information

  • CAS No. 1082066-29-2
  • Cat. No. CS-0097682
  • Purity ≥97%
  • MDL No. MFCD18732617
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₈BFO₃
  • Molecular Weight 252.09
  • Synonym(s) None
  • SMILES OCC1=CC=C(C=C1F)B2OC(C)(C(C)(O2)C)C

Description

This boronate ester features a fluorinated aryl moiety paired with a methanol handle, enabling direct incorporation into Suzuki-Miyaura couplings. The tetramethyl-1,3,2-dioxaborolane group ensures high stability and reactivity under standard conditions.

Application

(2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol serves as a versatile boronate building block for Suzuki-Miyaura cross-coupling reactions. The pendant alcohol group offers a handle for derivatization or protection, while the tetramethyl-substituted boronate ensures excellent bench stability and functional group tolerance. Its compatibility with a wide range of aryl and heteroaryl electrophiles enables efficient construction of biaryl and substituted phenyl scaffolds in medicinal chemistry and materials synthesis.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   38.69
  • LogP   1.6172
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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