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Structure of 1075753-27-3
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2-Chloro-7-(trifluoromethyl)-1H-benzimidazole features a trifluoromethyl group that imparts enhanced electron-withdrawing character and metabolic stability. This substitution pattern improves solubility in organic solvents and supports efficient coupling reactions under standard conditions. The molecule serves as a key scaffold in bioactive heterocycle synthesis, particularly in pharmaceutical intermediates requiring halogen-directed functionalization.
2-Chloro-7-(trifluoromethyl)-1H-benzimidazole serves as a versatile building block in medicinal chemistry, enabling direct incorporation of electron-withdrawing trifluoromethyl and halogen functionalities into heterocyclic scaffolds. Its reactivity profile supports palladium-catalyzed cross-coupling reactions, facilitating the construction of biaryl systems under standard conditions. The compound exhibits good bench stability and is compatible with common protecting group strategies, making it well-suited for iterative synthesis campaigns targeting pharmaceutical intermediates and functional materials.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: