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1-Isopropyl-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine

  • CAS No. 1073354-18-3

  • Cat. No. CS-0108726
  • Purity≥98%
  • MDL No.MFCD06795656

*For research and further manufacturing use only, not for direct human use.

1-Isopropyl-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine|CS-0108726

Structure of 1073354-18-3

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General Information

  • CAS No. 1073354-18-3
  • Cat. No. CS-0108726
  • Purity ≥98%
  • MDL No. MFCD06795656
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₉H₃₁BN₂O₂
  • Molecular Weight 330.27
  • Synonym(s) 4-(4-Isopropylpiperizinyl)Phenylboronic Acid, Pinacol Ester
  • SMILES CC(N1CCN(C2=CC=C(B3OC(C)(C)C(C)(C)O3)C=C2)CC1)C

Description

1-Isopropyl-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine is a bench-stable boronate reagent featuring a piperazine scaffold and a para-substituted arylboronate moiety. This structure enables efficient Suzuki-Miyaura cross-coupling reactions under mild conditions, delivering complex biaryl architectures with high functional group tolerance.

Application

1-Isopropyl-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine serves as a versatile boronate building block in Suzuki-Miyaura cross-coupling reactions. Its stability under ambient conditions and tolerance to diverse functional groups enable reliable incorporation into complex molecular architectures. The tetramethyl-substituted dioxaborolane moiety facilitates efficient coupling with aryl halides and pseudohalides, making it well-suited for constructing biaryl scaffolds in medicinal chemistry and materials synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   24.94
  • LogP   2.5162
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   3

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