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Structure of 107317-58-8
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Methyl 4-bromo-3-(trifluoromethyl)benzoate features a trifluoromethyl group positioned ortho to a bromine substituent on the aromatic ring, enhancing electron-withdrawing character and metabolic stability. This combination enables efficient cross-coupling reactions under palladium catalysis, delivering complex substituted arenes with high regiocontrol. The ester functionality supports further derivatization via hydrolysis or nucleophilic substitution.
Methyl 4-bromo-3-(trifluoromethyl)benzoate serves as a versatile building block in medicinal chemistry and materials science, enabling palladium-catalyzed cross-coupling reactions due to its stable bromo and ester functionalities. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the methyl ester allows for straightforward derivatization. Its bench-stable nature and compatibility with standard synthetic protocols facilitate efficient access to complex aromatic scaffolds.
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: