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CS-W001157 4
Total: USD 88.00

3,6-Dichloro-4-isopropylpyridazine

  • CAS No. 107228-51-3

  • Cat. No. CS-0056804
  • Purity≥96%
  • MDL No.MFCD18250571

*For research and further manufacturing use only, not for direct human use.

3,6-Dichloro-4-isopropylpyridazine|CS-0056804

Structure of 107228-51-3

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General Information

  • CAS No. 107228-51-3
  • Cat. No. CS-0056804
  • Purity ≥96%
  • MDL No. MFCD18250571
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈Cl₂N₂
  • Molecular Weight 191.06
  • Synonym(s) 3,6-dichloro-4-isopropylpyridazine, Fandachem
  • SMILES CC(C1=CC(Cl)=NN=C1Cl)C

Description

3,6-Dichloro-4-isopropylpyridazine is a halogenated pyridazine derivative featuring two chlorine substituents at positions 3 and 6, flanked by an isopropyl group at the 4-position. This electron-deficient heterocycle serves as a key intermediate in medicinal chemistry, enabling direct functionalization via cross-coupling reactions. The molecule exhibits enhanced stability under standard conditions and facilitates efficient incorporation into bioactive scaffolds through its reactive halogen sites.

Application

3,6-Dichloro-4-isopropylpyridazine serves as a versatile building block in medicinal chemistry, enabling the construction of nitrogen-containing heterocycles via palladium-catalyzed cross-coupling reactions. The dichloro substitution pattern facilitates sequential functionalization, while the isopropyl group provides steric and electronic modulation. This compound exhibits bench stability and compatibility with standard synthetic protocols, making it suitable for modular library synthesis and API intermediate development.

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2810
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H311-H331
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P405-P501

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   2.9068
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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