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CS-W001157 4
Total: USD 88.00

5-Bromo-6-fluoroquinoline

  • CAS No. 107224-21-5

  • Cat. No. CS-0130777
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Bromo-6-fluoroquinoline|CS-0130777

Structure of 107224-21-5

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General Information

  • CAS No. 107224-21-5
  • Cat. No. CS-0130777
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₅BrFN
  • Molecular Weight 226.05
  • Synonym(s) None
  • SMILES FC1=CC=C2N=CC=CC2=C1Br

Description

5-Bromo-6-fluoroquinoline is a halogenated quinoline derivative featuring complementary electrophilic and nucleophilic sites. This electron-deficient heterocycle enables efficient coupling reactions under mild conditions, serving as a key scaffold in medicinal chemistry and materials science applications.

Application

5-Bromo-6-fluoroquinoline serves as a versatile building block in medicinal chemistry and materials science, enabling direct functionalization at both the 5- and 6-positions. Its halogenated quinoline core facilitates palladium-catalyzed cross-coupling reactions, including Suzuki, Stille, and Negishi couplings, with high efficiency and selectivity. The molecule exhibits excellent bench stability, ease of purification, and compatibility with diverse protecting groups, making it well-suited for iterative synthesis of complex heterocyclic scaffolds and API intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H332-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   3.1364
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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