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Structure of 1072153-65-1
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6-Fluoro-2,3-dihydrobenzofuran is a bench-stable, electron-deficient heterocycle featuring a fluorine atom at the 6-position and a saturated furan ring. This structural motif integrates readily into bioactive molecules, offering enhanced metabolic stability and modulated lipophilicity. Its rigid, planar geometry facilitates precise molecular positioning in target binding sites.
6-Fluoro-2,3-dihydrobenzofuran serves as a versatile scaffold in medicinal chemistry, offering enhanced metabolic stability and modulated lipophilicity compared to its parent benzofuran. The fluorine substituent at the 6-position provides favorable electronic effects and improves binding affinity in target-directed synthesis. Its saturated furan ring enables compatibility with standard coupling reactions and functional group transformations, facilitating downstream derivatization. Bench-stable and readily purified by flash chromatography, it functions effectively as a building block for bioactive heterocycles and API intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: