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2-Bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-imidazole

  • CAS No. 1065483-60-4

  • Cat. No. CS-0099102
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-imidazole|CS-0099102

Structure of 1065483-60-4

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General Information

  • CAS No. 1065483-60-4
  • Cat. No. CS-0099102
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₁BrN₂O
  • Molecular Weight 231.09
  • Synonym(s) 2-Bromo-1-(tetrahydro-pyran-2-yl)-1H-imidazole
  • SMILES BrC1=NC=CN1C2CCCCO2

Description

2-Bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-imidazole serves as a stable, moisture-tolerant imidazole derivative featuring a protected hydroxyl group. This bench-stable reagent integrates readily into synthetic sequences requiring selective C–H functionalization or heterocycle coupling, delivering high yields under mild conditions.

Application

2-Bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-imidazole serves as a stable, bench-accessible imidazole building block enabling direct C2 functionalization in heterocyclic synthesis. The tetrahydro-2H-pyran-2-yl protecting group offers excellent stability under standard reaction conditions and can be readily removed via mild acidolysis, facilitating downstream derivatization. This compound functions effectively in palladium-catalyzed cross-coupling reactions and provides orthogonal reactivity for late-stage modification in medicinal chemistry and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   27.05
  • LogP   2.3447
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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