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CS-W001157 4
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2-(3,5-Difluorophenyl)propan-2-amine hydrochloride

  • CAS No. 1063733-81-2

  • Cat. No. CS-0060972
  • Molecule weight207.65
  • Purity≥98%
  • MDL No.MFCD19687116

*For research and further manufacturing use only, not for direct human use.

2-(3,5-Difluorophenyl)propan-2-amine hydrochloride|CS-0060972

Structure of 1063733-81-2

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General Information

  • CAS No. 1063733-81-2
  • Cat. No. CS-0060972
  • Purity ≥98%
  • MDL No. MFCD19687116
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₂ClF₂N
  • Molecular Weight 207.65
  • Synonym(s) 2-(3,5-difluorophenyl)propan-2-amine HCl
  • SMILES NC(C)(C)C1=CC(F)=CC(F)=C1.[H]Cl

Description

This bench-stable hydrochloride salt features a sterically hindered tertiary amine core bearing a 3,5-difluorophenyl group, enabling efficient incorporation into chiral auxiliaries and pharmaceutical intermediates. The electron-deficient aromatic ring enhances reactivity in coupling processes, while the protonated amine ensures solubility in polar media and facilitates purification via salt formation.

Application

2-(3,5-Difluorophenyl)propan-2-amine hydrochloride serves as a valuable building block in medicinal chemistry, enabling the synthesis of fluorinated arylpropanamine scaffolds prevalent in CNS-targeted therapeutics. Its bench-stable hydrochloride salt form facilitates handling and purification, while the tertiary amine functionality offers reliable reactivity in amide coupling and electrophilic substitution reactions. The 3,5-difluoro substitution pattern enhances metabolic stability and modulates lipophilicity, supporting efficient incorporation into complex molecular architectures.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.5804
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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