3-(4-Hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione

Name: 3-(4-Hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Brand: ChemScene
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CAS No. 1061604-41-8
Cat. No. CS-0112805
Purity≥97%
MDL No.MFCD29054753

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Type	HazMat Fee
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FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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3-(4-Hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione|CS-0112805

Structure of 1061604-41-8

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General Information

CAS No. 1061604-41-8
Cat. No. CS-0112805
Purity ≥97%
MDL No. MFCD29054753
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₃H₁₂N₂O₄
Molecular Weight None
Synonym(s) None
SMILES O=C(C(N(CC1=C2C=CC=C1O)C2=O)CC3)NC3=O

Description

This piperidine-2,6-dione derivative features a hydroxyisoindolinone moiety that enhances solubility and enables selective bioconjugation. The scaffold integrates a sterically hindered amide linkage and electron-deficient aromatic system, supporting stability under standard conditions. Designed for use in targeted drug delivery systems and medicinal chemistry libraries, it facilitates efficient coupling reactions without requiring extensive purification.

Application

3-(4-Hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione serves as a versatile scaffold for medicinal chemistry campaigns, enabling efficient access to complex heterocyclic architectures. The molecule combines a hydroxylated isoindolinone core with a diketopiperazine moiety, offering multiple sites for derivatization. Its bench-stable nature and compatibility with standard coupling reactions facilitate rapid analog synthesis. Functions effectively in the construction of bioactive molecules requiring fused ring systems and hydrogen-bonding capabilities.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H312-H315-H319
Precautionary Statements : P264-P270-P280-P302+P352-P330-P362+P364-P501

Quality Control

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Computational Chemistry Data

TPSA 86.71
LogP -0.4067
H_Acceptors 6
H_Donors 2
Rotatable_Bonds 1

Other Classifications

Life Science PROTAC Ligands for E3 Ligase

Building Blocks Functional Group Amine

Building Blocks Functional Group Phenol

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Aromatic heterocycle compounds Other aromatic heterocycles compounds

Analytical Science Drug Impurity Reference Substance Anti-Tumor Drugs Lenalidomide impurity

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Proteolysis Targeting Chimera Research Reagents

Biochemistry Pharmaceutical Development and Drug Discovery Research Proteolysis Targeting Chimera Research Reagents

Key Words

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3-(4-Hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione

CAS No. 1061604-41-8

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