tert-Butyl 7-chloro-3,4-dihydro-2,6-naphthyridine-2(1H)-carboxylate

Name: tert-Butyl 7-chloro-3,4-dihydro-2,6-naphthyridine-2(1H)-carboxylate
Brand: ChemScene
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CAS No. 1060816-50-3
Cat. No. CS-0120176
Purity≥95%
MDL No.MFCD13189403

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tert-Butyl 7-chloro-3,4-dihydro-2,6-naphthyridine-2(1H)-carboxylate|CS-0120176

Structure of 1060816-50-3

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General Information

CAS No. 1060816-50-3
Cat. No. CS-0120176
Purity ≥95%
MDL No. MFCD13189403
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₃H₁₇ClN₂O₂
Molecular Weight 268.74
Synonym(s) tert-butyl 7-chloro-3,4-dihydro-1H-2,6-naphthyridine-2-carboxylate
SMILES O=C(N1CC2=C(C=NC(Cl)=C2)CC1)OC(C)(C)C

Description

tert-Butyl 7-chloro-3,4-dihydro-2,6-naphthyridine-2(1H)-carboxylate features a chlorinated naphthyridine core with a bench-stable tert-butyl ester, enabling straightforward deprotection and functionalization. This electron-deficient scaffold integrates readily into medicinal chemistry campaigns targeting kinase inhibitors and CNS-active compounds.

Application

tert-Butyl 7-chloro-3,4-dihydro-2,6-naphthyridine-2(1H)-carboxylate serves as a versatile building block for the synthesis of naphthyridine-based scaffolds. The chloro group enables palladium-catalyzed cross-coupling reactions, while the dihydro-2(1H)-carboxylate functionality offers compatibility with standard deprotection and functionalization protocols. Bench-stable and readily purified, it facilitates efficient access to biologically relevant heterocycles in medicinal chemistry and agrochemical research.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 42.43
LogP 3.0282
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Amine

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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tert-Butyl 7-chloro-3,4-dihydro-2,6-naphthyridine-2(1H)-carboxylate

CAS No. 1060816-50-3

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