2-Bromo-5-chloropyridin-4-amine

Name: 2-Bromo-5-chloropyridin-4-amine
Brand: ChemScene
Availability: InStock
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CAS No. 1060815-72-6
Cat. No. CS-0469032
Purity≥98%
MDL No.MFCD12400754

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Bromo-5-chloropyridin-4-amine|CS-0469032

Structure of 1060815-72-6

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Description

2-Bromo-5-chloropyridin-4-amine features a pyridine core functionalized with bromo and chloro substituents at the 2- and 5-positions, respectively, and a primary amine group at the 4-position. This electron-deficient heterocycle serves as a key building block in medicinal chemistry, enabling direct coupling reactions under palladium catalysis. The molecule exhibits good stability under standard handling conditions and integrates readily into complex scaffolds for drug discovery programs.

Application

2-Bromo-5-chloropyridin-4-amine serves as a versatile building block in medicinal chemistry and heterocyclic synthesis. Its dual halogen substituents enable selective cross-coupling reactions, including Suzuki-Miyaura and Buchwald-Hartwig couplings, facilitating the construction of complex biaryl and amine-containing scaffolds. The pyridinamine functionality provides a handle for further derivatization, while the compound exhibits sufficient bench stability for routine handling and purification.

General Information

CAS No. 1060815-72-6
Cat. No. CS-0469032
Purity ≥98%
MDL No. MFCD12400754
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₄BrClN₂
Molecular Weight None
Synonym(s) 4-Amino-2-bromo-5-chloropyridine
SMILES NC1=CC(Br)=NC=C1Cl

Computational Chemistry Data

TPSA 38.91
LogP 2.0797
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS06
Signal Word : Danger	UN#: 2811
Class : 6.1	Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P264-P270-P301+P310-P330-P405-P501

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Bromo-5-chloropyridin-4-amine

CAS No. 1060815-72-6

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