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CS-W001157 4
Total: USD 88.00

4-Amino-6-chloronicotinic acid

  • CAS No. 1060811-65-5

  • Cat. No. CS-0043764
  • Purity≥98%
  • MDL No.MFCD00234161

*For research and further manufacturing use only, not for direct human use.

4-Amino-6-chloronicotinic acid|CS-0043764

Structure of 1060811-65-5

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General Information

  • CAS No. 1060811-65-5
  • Cat. No. CS-0043764
  • Purity ≥98%
  • MDL No. MFCD00234161
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅ClN₂O₂
  • Molecular Weight 172.57
  • Synonym(s) 4-Amino-6-chloro-3- pyridinecarboxylic acid
  • SMILES O=C(O)C1=CN=C(Cl)C=C1N

Description

4-Amino-6-chloronicotinic acid is a bench-stable heterocyclic building block featuring an electron-rich amino group and a reactive chloro substituent at adjacent ring positions. This combination enables direct functionalization in cross-coupling and amide coupling reactions, streamlining access to bioactive nitrogen-containing scaffolds in medicinal chemistry and agrochemical development.

Application

4-Amino-6-chloronicotinic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of heterocyclic scaffolds and bioactive molecules. Its ortho-chloro and amino groups provide complementary sites for nucleophilic substitution, palladium-catalyzed coupling, and amide formation, with demonstrated stability under standard bench conditions and compatibility with common protecting group strategies.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   76.21
  • LogP   1.0154
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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