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CS-W001157 4
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1-(2-(Trifluoromethyl)pyridin-4-yl)ethanone

  • CAS No. 1060810-86-7

  • Cat. No. CS-0155103
  • Molecule weight189.13
  • Purity≥97%
  • MDL No.MFCD11847720

*For research and further manufacturing use only, not for direct human use.

1-(2-(Trifluoromethyl)pyridin-4-yl)ethanone|CS-0155103

Structure of 1060810-86-7

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General Information

  • CAS No. 1060810-86-7
  • Cat. No. CS-0155103
  • Purity ≥97%
  • MDL No. MFCD11847720
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆F₃NO
  • Molecular Weight 189.13
  • Synonym(s) None
  • SMILES CC(=O)C1=CC(=NC=C1)C(F)(F)F

Description

1-(2-(Trifluoromethyl)pyridin-4-yl)ethanone features a trifluoromethyl-pyridine scaffold paired with an electrophilic ketone group, enabling direct integration into C–C bond formation reactions. This bench-stable, moisture-tolerant building block facilitates efficient access to complex heterocyclic architectures in medicinal chemistry and materials science.

Application

1-(2-(Trifluoromethyl)pyridin-4-yl)ethanone serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyridine-based pharmacophores. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the acetyl functionality facilitates nucleophilic substitution, reduction, or coupling reactions. The compound exhibits good bench stability and is compatible with standard synthetic workflows, making it well-suited for rapid diversification in target-oriented synthesis.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   2.303
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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