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CS-W001157 4
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4-Amino-2-bromonicotinic acid

  • CAS No. 1060809-71-3

  • Cat. No. CS-0155601
  • Molecule weight217.02
  • Purity≥95%
  • MDL No.MFCD13189282

*For research and further manufacturing use only, not for direct human use.

4-Amino-2-bromonicotinic acid|CS-0155601

Structure of 1060809-71-3

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General Information

  • CAS No. 1060809-71-3
  • Cat. No. CS-0155601
  • Purity ≥95%
  • MDL No. MFCD13189282
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅BrN₂O₂
  • Molecular Weight 217.02
  • Synonym(s) 4-AMino-2-broMo-nicotinic acid
  • SMILES C1=CN=C(C(=C1N)C(=O)O)Br

Description

4-Amino-2-bromonicotinic acid is a functionalized pyridine carboxylic acid featuring a bromine atom at the 2-position and an amino group at the 4-position, enabling selective derivatization in synthetic chemistry. This electron-deficient scaffold integrates readily into bioactive molecule design, offering enhanced reactivity in cross-coupling and amidation processes under standard conditions.

Application

4-Amino-2-bromonicotinic acid serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. The ortho-bromo and para-amino groups enable sequential functionalization via Pd-catalyzed cross-coupling and directed metalation reactions. Its stability under standard reaction conditions and compatibility with common protecting group strategies facilitate efficient access to complex scaffolds in medicinal chemistry and process development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   76.21
  • LogP   1.1245
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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