(R)-6-Fluoro-1,2,3,4-tetrahydronaphthalen-1-amine

Name: (R)-6-Fluoro-1,2,3,4-tetrahydronaphthalen-1-amine
Brand: ChemScene
Availability: InStock
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CAS No. 1057246-78-2
Cat. No. CS-0200329
Molecule weight165.21
Purity≥97%
MDL No.None

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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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(R)-6-Fluoro-1,2,3,4-tetrahydronaphthalen-1-amine|CS-0200329

Structure of 1057246-78-2

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General Information

CAS No. 1057246-78-2
Cat. No. CS-0200329
Purity ≥97%
MDL No. None
Storage 4°C, protect from light, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₂FN
Molecular Weight 165.21
Synonym(s) (R)-6-Fluoro-1,2,3,4-tetrahydro-phthalen-1-ylamine
SMILES N[C@@H]1CCCC2=C1C=CC(F)=C2

Description

(R)-6-Fluoro-1,2,3,4-tetrahydronaphthalen-1-amine is a chiral amine scaffold featuring a fluorinated tetralin core with defined stereochemistry at the nitrogen-bearing carbon. This bench-stable, moisture-tolerant compound serves as a key building block in asymmetric synthesis and medicinal chemistry, where its electron-deficient aromatic ring enhances reactivity in coupling processes.

Application

(R)-6-Fluoro-1,2,3,4-tetrahydronaphthalen-1-amine serves as a chiral building block for bioactive molecules, offering a fluorinated tetralin scaffold with defined stereochemistry. Its amine functionality enables straightforward derivatization via alkylation, acylation, or reductive amination, while the fluoro substituent provides metabolic stability and modulates electronic properties. Bench-stable and readily purified, it functions effectively in medicinal chemistry campaigns targeting CNS agents and kinase inhibitors.

Safety Information

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GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 3267
Class : 8	Packing Group : Ⅲ
Hazard Statements : H302-H318
Precautionary Statements : P264-P270-P280-P330-P501

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Computational Chemistry Data

TPSA 26.02
LogP 2.1618
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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(R)-6-Fluoro-1,2,3,4-tetrahydronaphthalen-1-amine

CAS No. 1057246-78-2

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