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CS-W001157 4
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7-Bromo-3,4-dihydro-2H-benzo[b][1,4]oxazine

  • CAS No. 105679-22-9

  • Cat. No. CS-W018893
  • Purity≥95%
  • MDL No.MFCD09056750

*For research and further manufacturing use only, not for direct human use.

7-Bromo-3,4-dihydro-2H-benzo[b][1,4]oxazine|CS-W018893

Structure of 105679-22-9

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General Information

  • CAS No. 105679-22-9
  • Cat. No. CS-W018893
  • Purity ≥95%
  • MDL No. MFCD09056750
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈BrNO
  • Molecular Weight 214.06
  • Synonym(s) 7-Bromo-3,4-dihydro-2H-benzo[1,4]oxazine
  • SMILES BrC1=CC2=C(C=C1)NCCO2

Description

7-Bromo-3,4-dihydro-2H-benzo[b][1,4]oxazine features a brominated heterocyclic core that enables direct functionalization in late-stage synthesis. This bench-stable scaffold integrates readily into pharmaceutical intermediates, offering high compatibility with palladium-catalyzed coupling reactions and favorable solubility across organic media.

Application

7-Bromo-3,4-dihydro-2H-benzo[b][1,4]oxazine serves as a versatile heterocyclic building block for medicinal chemistry and synthetic organic applications. The bromine substituent enables palladium-catalyzed cross-coupling reactions, while the dihydrooxazine core offers moderate stability and compatibility with standard functional group manipulations. Its defined stereochemistry and bench-stable nature facilitate reliable incorporation into complex molecular architectures.

Synthesis

  • Route1
    • null|null
      280142-79-2
    • ~%
    • In-stock
      7-Bromo-3,4-dihydro-2H-benzo[b][1,4]oxazine|CS-W018893
      105679-22-9

    References

    • US6632814 B1, ; Page/Page column 334 ;
  • Route2

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 16 p. 4700 - 4704

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   21.26
  • LogP   2.2534
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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