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CS-W001157 4
Total: USD 88.00

7-Chloro-1H-indole-6-carboxylic acid

  • CAS No. 1055320-72-3

  • Cat. No. CS-0375506
  • Purity≥98%
  • MDL No.MFCD16658588

*For research and further manufacturing use only, not for direct human use.

7-Chloro-1H-indole-6-carboxylic acid|CS-0375506

Structure of 1055320-72-3

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General Information

  • CAS No. 1055320-72-3
  • Cat. No. CS-0375506
  • Purity ≥98%
  • MDL No. MFCD16658588
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₆ClNO₂
  • Molecular Weight 195.60
  • Synonym(s) None
  • SMILES O=C(C1=C(Cl)C2=C(C=C1)C=CN2)O

Description

7-Chloro-1H-indole-6-carboxylic acid features a chlorinated indole core with a carboxylic acid group at the 6-position, enabling direct conjugation in bioactive molecule synthesis. The electron-deficient aromatic system enhances reactivity in coupling reactions, while the bench-stable functionality supports efficient integration into pharmaceutical and agrochemical scaffolds under standard conditions.

Application

7-Chloro-1H-indole-6-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling direct incorporation into bioactive heterocycles via standard coupling reactions. Its ortho-chloro substituent enhances electrophilic reactivity and facilitates downstream functionalization, while the carboxylic acid group supports efficient amide and ester formation. The compound exhibits good bench stability and compatibility with common purification methods, making it well-suited for iterative synthesis campaigns targeting kinase inhibitors and CNS-active scaffolds.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H315-H319-H332-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   53.09
  • LogP   2.5195
  • H_Acceptors   1
  • H_Donors   2
  • Rotatable_Bonds   1

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