4-(4-(Trifluoromethyl)phenyl)thiazol-2-amine

Name: 4-(4-(Trifluoromethyl)phenyl)thiazol-2-amine
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CAS No. 105512-79-6
Cat. No. CS-0165853
Molecule weight244.24
Purity≥98%
MDL No.MFCD03094298

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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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4-(4-(Trifluoromethyl)phenyl)thiazol-2-amine|CS-0165853

Structure of 105512-79-6

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General Information

CAS No. 105512-79-6
Cat. No. CS-0165853
Purity ≥98%
MDL No. MFCD03094298
Storage 4°C, protect from light, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₇F₃N₂S
Molecular Weight 244.24
Synonym(s) 4-[4-(Trifluoromethyl)phenyl]-1,3-thiazol-2-amine
SMILES NC1=NC(C2=CC=C(C(F)(F)F)C=C2)=CS1

Description

This thiazole derivative features a trifluoromethyl-substituted phenyl group linked to a thiazol-2-amine core, delivering enhanced electron-withdrawing character and metabolic stability. The scaffold integrates readily into bioactive molecules, particularly in kinase inhibitors and fluorescent probes, where its planar structure supports π-stacking interactions.

Application

4-(4-(Trifluoromethyl)phenyl)thiazol-2-amine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling and functionalization reactions. Its trifluoromethyl aryl group enhances metabolic stability and lipophilicity, while the thiazole amine functionality provides a robust site for derivatization. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis campaigns in API development.

Safety Information

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GHS Pictogram :	GHS No : GHS06
Signal Word : Danger	UN#: 2811
Class : 6.1	Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P264-P270-P330-P405-P501

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Computational Chemistry Data

TPSA 38.91
LogP 3.4111
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic heterocycle compounds Thiazole compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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4-(4-(Trifluoromethyl)phenyl)thiazol-2-amine

CAS No. 105512-79-6

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