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CS-W001157 4
Total: USD 88.00

4-(P-Tolyl)thiazol-2-amine

  • CAS No. 2103-91-5

  • Cat. No. CS-0022329
  • Purity≥98%
  • MDL No.MFCD00170264

*For research and further manufacturing use only, not for direct human use.

4-(P-Tolyl)thiazol-2-amine|CS-0022329

Structure of 2103-91-5

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General Information

  • CAS No. 2103-91-5
  • Cat. No. CS-0022329
  • Purity ≥98%
  • MDL No. MFCD00170264
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₀N₂S
  • Molecular Weight 190.26
  • Synonym(s) 4-p-Tolylthiazol-2-ylamine; 4-(p-Tolyl)-2-thiazolamine
  • SMILES NC1=NC(C2=CC=C(C)C=C2)=CS1

Description

4-(p-Tolyl)thiazol-2-amine features a thiazole core functionalized with a para-tolyl group and an amine at the 2-position, delivering enhanced electron density and stability. This scaffold integrates readily into heterocyclic architectures, serving as a key building block in medicinal chemistry and materials science applications.

Application

4-(p-Tolyl)thiazol-2-amine serves as a versatile building block in medicinal chemistry, enabling the construction of thiazole-based scaffolds with demonstrated utility in kinase inhibitor and bioactive heterocycle development. Its robust bench stability, compatibility with standard coupling reactions, and tolerance to diverse functional groups facilitate efficient synthesis and purification in multi-step workflows.

Synthesis

  • Route1
    • null|null
      17356-08-0
    • In-stock
      2-Bromo-1-(p-tolyl)ethanone|CS-W007335
      619-41-0
    • ~98%
    • In-stock
      4-(P-Tolyl)thiazol-2-amine|CS-0022329
      2103-91-5

    References

    • TAIVEX THERAPEUTICS CORPORATION; HUANG, Yu-Ling; CHUANG, Shih-Hsien; LEE, Ying-Shuan Eda; HUANG, Jiann-Jyh; LAU, Johnson Patent: WO2013/82324 A1, 2013 ; Location in patent: Paragraph 00265 ;
  • Route2
    • null|null
      17356-08-0
    • 4'-Methylacetophenone, ≥95%|CS-1269192
      122-00-9
    • ~78%
    • In-stock
      4-(P-Tolyl)thiazol-2-amine|CS-0022329
      2103-91-5

    References

    • Caceres-Castillo, David; Carballo, Ruben M.; Tzec-Interian, Jorge A.; Mena-Rejon, Gonzalo J. Tetrahedron Letters, 2012 , vol. 53, # 30 p. 3934 - 3936
  • Route3
    • 4'-Methylacetophenone, ≥95%|CS-1269192
      122-00-9
    • ~55%
    • In-stock
      4-(P-Tolyl)thiazol-2-amine|CS-0022329
      2103-91-5

    References

    • SAWAI PHARMACEUTICAL CO., LTD. Patent: EP321115 B1, 1991 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302+H312+H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   2.70072
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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