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1-(3,4-Dimethoxyphenyl)-2-(2-methoxyphenoxy)-1,3-propanediol

  • CAS No. 10535-17-8

  • Cat. No. CS-D0574
  • Purity≥95%
  • MDL No.MFCD01880862

*For research and further manufacturing use only, not for direct human use.

1-(3,4-Dimethoxyphenyl)-2-(2-methoxyphenoxy)-1,3-propanediol|CS-D0574

Structure of 10535-17-8

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General Information

  • CAS No. 10535-17-8
  • Cat. No. CS-D0574
  • Purity ≥95%
  • MDL No. MFCD01880862
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₈H₂₂O₆
  • Molecular Weight 334.36
  • Synonym(s) veratrylglycerol-beta-guaiacyl ether
  • SMILES OC(C(CO)OC1=CC=CC=C1OC)C2=CC=C(OC)C(OC)=C2

Description

This propanediol features a dimethoxyphenyl moiety and a methoxyphenoxy group, offering enhanced solubility and stability in polar organic solvents. The electron-rich aromatic systems facilitate efficient coupling reactions, while the hydroxyl groups enable further functionalization.

Application

1-(3,4-Dimethoxyphenyl)-2-(2-methoxyphenoxy)-1,3-propanediol serves as a versatile polyfunctional building block for the synthesis of bioactive heterocycles and complex natural product analogs. Its ortho-dimethoxyaryl and phenoxy substituents enable selective functionalization in palladium-catalyzed couplings, while the propanediol backbone offers orthogonal protection options. Bench-stable and amenable to standard purification methods, it facilitates efficient assembly of pharmaceutically relevant scaffolds.

Synthesis

  • Route1

    References

    • Nguyen, John D.; Matsuura, Bryan S.; Stephenson, Corey R. J. Journal of the American Chemical Society, 2014 , vol. 136, # 4 p. 1218 - 1221
  • Route2
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    • In-stock
      1-(3,4-Dimethoxyphenyl)-2-(2-methoxyphenoxy)-1,3-propanediol|CS-D0574
      10535-17-8

    References

    • Journal of Organic Chemistry, , vol. 27, p. 2111 - 2114
  • Route3

    References

    • Journal of Organic Chemistry, , vol. 27, p. 2111 - 2114

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   77.38
  • LogP   2.1857
  • H_Acceptors   6
  • H_Donors   2
  • Rotatable_Bonds   8

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