Lot numbers can be found on the outside label of a product:
4-(4-Aminophenyl)thiomorpholine 1,1-dioxide
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CAS No. 105297-10-7
- Cat. No. CS-0146891
- Purity≥98%
- MDL No.MFCD06797046
*For research and further manufacturing use only, not for direct human use.
Structure of 105297-10-7
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General Information
- CAS No. 105297-10-7
- Cat. No. CS-0146891
- Purity ≥98%
- MDL No. MFCD06797046
- Storage RT, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₀H₁₄N₂O₂S
- Molecular Weight 226.30
- Synonym(s) 4-Thiomorpholinoaniline 1',1'-Dioxide
- SMILES NC1=CC=C(N2CCS(CC2)(=O)=O)C=C1
Description
4-(4-Aminophenyl)thiomorpholine 1,1-dioxide features a sulfonamide-linked arylamine moiety with enhanced solubility and metabolic stability. This electron-deficient heterocycle integrates readily into kinase inhibitor scaffolds and serves as a key pharmacophore in targeted therapeutics.
Application
4-(4-Aminophenyl)thiomorpholine 1,1-dioxide serves as a versatile building block in medicinal chemistry, enabling the construction of diverse heterocyclic scaffolds through standard coupling reactions. Its amine functionality facilitates direct derivatization, while the sulfonamide-like thiomorpholine 1,1-dioxide moiety provides enhanced solubility and metabolic stability. The compound exhibits excellent bench stability and compatibility with common reaction conditions, making it ideal for iterative synthesis campaigns and API development.
Synthesis
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Route1
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329943-64-8 - ~49%
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In-stock
105297-10-7
References
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F2G LTD Patent: WO2008/62182 A1, 2008 ; Location in patent: Page/Page column 155 ;
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Route2
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In-stock
350-46-9 - ~%
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In-stock
105297-10-7
References
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WO2012/59932 A1, ; WO 2012/059932 A1
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Route3
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90254-22-1 - ~%
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In-stock
105297-10-7
References
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WO2012/59932 A1, ; WO 2012/059932 A1
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319
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Precautionary Statements : P264-P280-P302+P352-P362+P364
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Quality Control
Computational Chemistry Data
- TPSA 63.4
- LogP 0.5036
- H_Acceptors 4
- H_Donors 1
- Rotatable_Bonds 1
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Key Words
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