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CS-W001157 4
Total: USD 88.00

4-(2-Bromopyridin-4-yl)morpholine

  • CAS No. 1049023-41-7

  • Cat. No. CS-0186858
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-(2-Bromopyridin-4-yl)morpholine|CS-0186858

Structure of 1049023-41-7

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General Information

  • CAS No. 1049023-41-7
  • Cat. No. CS-0186858
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₁BrN₂O
  • Molecular Weight 243.10
  • Synonym(s) None
  • SMILES C1=CN=C(C=C1N2CCOCC2)Br

Description

4-(2-Bromopyridin-4-yl)morpholine features a brominated pyridine moiety coupled to a morpholine ring, enabling efficient coupling in cross-coupling reactions. The electron-rich morpholine enhances solubility and reactivity, while the bromine serves as a reliable handle for palladium-mediated transformations. This structure combines synthetic versatility with bench-stable handling.

Application

4-(2-Bromopyridin-4-yl)morpholine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions for the construction of biaryl and heteroaryl scaffolds. The bromopyridine moiety offers high reactivity in Suzuki, Stille, and Buchwald–Hartwig couplings, while the morpholine ring provides solubility and metabolic stability. Bench-stable and readily purified by column chromatography, it functions efficiently in multi-step synthesis of kinase inhibitors and other bioactive molecules.

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P264-P270-P330-P405-P501

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Computational Chemistry Data

  • TPSA   25.36
  • LogP   1.6807
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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