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CS-W001157 4
Total: USD 88.00

5-Methylpyrazolo[1,5-a]pyridine

  • CAS No. 104468-72-6

  • Cat. No. CS-0437373
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Methylpyrazolo[1,5-a]pyridine|CS-0437373

Structure of 104468-72-6

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General Information

  • CAS No. 104468-72-6
  • Cat. No. CS-0437373
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈N₂
  • Molecular Weight 132.16
  • Synonym(s) None
  • SMILES CC1=CC2=CC=NN2C=C1

Description

5-Methylpyrazolo[1,5-a]pyridine is a heterocyclic scaffold featuring fused pyrazole and pyridine rings with a methyl substituent at the 5-position. This electron-rich system exhibits enhanced stability and solubility in organic media, enabling straightforward incorporation into medicinal chemistry libraries. The rigid, planar geometry facilitates π-stacking interactions in target binding, making it a valuable core for kinase inhibitors and other bioactive compounds.

Application

5-Methylpyrazolo[1,5-a]pyridine serves as a versatile heterocyclic building block for medicinal chemistry and materials science applications. Its fused tricyclic structure provides enhanced metabolic stability and favorable π-stacking interactions, enabling efficient incorporation into kinase inhibitors and fluorescent probes. The methyl group at the 5-position offers a site for further functionalization via electrophilic substitution or cross-coupling reactions, while the scaffold exhibits excellent bench stability and compatibility with standard purification techniques.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   17.3
  • LogP   1.64272
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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