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CS-W001157 4
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4-Fluoro-1H-indazole-5-carboxylic acid

  • CAS No. 1041481-59-7

  • Cat. No. CS-0042873
  • Purity≥98%
  • MDL No.MFCD11007930

*For research and further manufacturing use only, not for direct human use.

4-Fluoro-1H-indazole-5-carboxylic acid|CS-0042873

Structure of 1041481-59-7

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General Information

  • CAS No. 1041481-59-7
  • Cat. No. CS-0042873
  • Purity ≥98%
  • MDL No. MFCD11007930
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅FN₂O₂
  • Molecular Weight 180.14
  • Synonym(s) 4-Fluoro (1H)indazole-5-carboxylic acid
  • SMILES O=C(C1=C(F)C2=C(NN=C2)C=C1)O

Description

4-Fluoro-1H-indazole-5-carboxylic acid features a fluorinated indazole core with a carboxylic acid group at the 5-position, enabling direct conjugation or derivatization. The electron-withdrawing fluorine enhances electrophilicity at the ring, while the carboxylic acid provides a handle for amide formation or salt generation. This combination supports integration into bioactive scaffolds and functional materials under standard bench conditions.

Application

4-Fluoro-1H-indazole-5-carboxylic acid serves as a versatile building block for medicinal chemistry and heterocyclic synthesis, enabling the construction of bioactive scaffolds through standard coupling reactions. Its fluorinated indazole core offers enhanced metabolic stability and modulated electronic properties, while the carboxylic acid functionality facilitates direct derivatization or incorporation into peptide-like frameworks. The compound exhibits good bench stability and is compatible with common protection and activation protocols.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   65.98
  • LogP   1.4002
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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