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Structure of 1041205-43-9
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1-(Difluoromethyl)-4-iodo-1H-pyrazole features a uniquely electron-deficient pyrazole core flanked by a difluoromethyl group and a reactive iodine handle. This combination enables direct functionalization in cross-coupling reactions, facilitating the construction of complex fluorinated heterocycles under mild conditions. The molecule exhibits enhanced stability and solubility in polar aprotic solvents, streamlining its integration into synthetic workflows for medicinal chemistry and materials science applications.
1-(Difluoromethyl)-4-iodo-1H-pyrazole serves as a versatile building block for constructing fluorinated heterocyclic scaffolds in medicinal chemistry. The difluoromethyl group imparts enhanced metabolic stability and modulates lipophilicity, while the iodine moiety enables palladium-catalyzed cross-coupling reactions such as Suzuki-Miyaura and Sonogashira couplings. Its bench-stable nature and compatibility with diverse functional groups facilitate efficient synthesis of complex molecular architectures.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: