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CS-W001157 4
Total: USD 88.00

N-Boc-2-(4-Aminophenyl)ethanol

  • CAS No. 104060-23-3

  • Cat. No. CS-W018890
  • Purity≥97%
  • MDL No.MFCD04974330

*For research and further manufacturing use only, not for direct human use.

N-Boc-2-(4-Aminophenyl)ethanol|CS-W018890

Structure of 104060-23-3

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General Information

  • CAS No. 104060-23-3
  • Cat. No. CS-W018890
  • Purity ≥97%
  • MDL No. MFCD04974330
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₉NO₃
  • Molecular Weight 237.30
  • Synonym(s) tert-butyl N-[4-(2-hydroxyethyl)phenyl]carbamate
  • SMILES C(=O)(OC(C)(C)C)NC1=CC=C(C=C1)CCO

Description

N-Boc-2-(4-Aminophenyl)ethanol features a protected primary amine tethered to a phenethyl scaffold, enabling direct incorporation into peptide and small-molecule libraries. The Boc group ensures stability during synthetic manipulations while allowing selective deprotection under mild acidic conditions. This compound serves as a key intermediate for bioactive molecule synthesis, particularly in kinase inhibitor development and functionalized arylamine architectures.

Application

N-Boc-2-(4-Aminophenyl)ethanol serves as a versatile building block for the synthesis of arylalkylamine-containing scaffolds. The Boc-protected amine enables orthogonal functional group manipulation, while the pendant phenolic hydroxyl supports direct derivatization or coupling reactions. This compound facilitates efficient access to bioactive heterocycles and pharmaceutical intermediates through standard amine deprotection and cross-coupling protocols.

Synthesis

  • Route1

    References

    • Medicinal Chemistry Research, , vol. 11, # 7 p. 380 - 398
  • Route2

    References

    • US2003/191126 A1, ;
  • Route3
    • null|null
      92814-31-8
    • tert-Butyl 1-(tert-butoxy)isoquinoline-2(1H)-carboxylate|CS-0135481
      404586-94-3
    • ~95%
    • In-stock
      N-Boc-2-(4-Aminophenyl)ethanol|CS-W018890
      104060-23-3

    References

    • Organic Letters, , vol. 4, # 4 p. 585 - 587 Tetrahedron, , vol. 62, # 50 p. 11599 - 11607

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   58.56
  • LogP   2.5684
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   3

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