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CS-W001157 4
Total: USD 88.00

1-Methylbenzoimidazol-5-amine

  • CAS No. 10394-38-4

  • Cat. No. CS-W006197
  • Purity≥97%
  • MDL No.MFCD03164349

*For research and further manufacturing use only, not for direct human use.

1-Methylbenzoimidazol-5-amine|CS-W006197

Structure of 10394-38-4

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General Information

  • CAS No. 10394-38-4
  • Cat. No. CS-W006197
  • Purity ≥97%
  • MDL No. MFCD03164349
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉N₃
  • Molecular Weight 147.18
  • Synonym(s) 1-METHYL-1H-BENZIMIDAZOL-5-YLAMINE
  • SMILES NC1=CC=C2C(N=CN2C)=C1

Description

1-Methylbenzoimidazol-5-amine features a methyl-substituted benzoimidazole core with a primary amine at the 5-position, delivering enhanced solubility and nucleophilicity. This scaffold integrates readily into heterocyclic architectures, serving as a key building block in medicinal chemistry and functional material synthesis under standard conditions.

Application

1-Methylbenzoimidazol-5-amine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling and functionalization reactions. Its well-defined reactivity profile, combined with bench stability and ease of purification, makes it suitable for use in multi-step syntheses targeting kinase inhibitors and other pharmaceutical scaffolds.

Synthesis

  • Route1
    • 1-Methyl-5-nitro-1H-benzo[d]imidazole|CS-0314716
      5381-78-2
    • ~97%
    • In-stock
      1-Methylbenzoimidazol-5-amine|CS-W006197
      10394-38-4

    References

    • Deciphera Pharmaceuticals, LLC Patent: US2008/90856 A1, 2008 ; Location in patent: Page/Page column 46-47 ; US 20080090856 A1
  • Route2

    References

    • Bioorganic and Medicinal Chemistry, , vol. 21, # 13 p. 3821 - 3830
  • Route3

    References

    • Journal of the Chemical Society of Pakistan, , vol. 35, # 5 p. 1343 - 1348

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   43.84
  • LogP   1.1555
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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