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Structure of 103878-60-0
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5-Bromo-2-chloro-1,3-thiazole-4-carboxylic acid features a dual halogenated thiazole core with orthogonal reactivity at C5 and C2, enabling selective functionalization. The carboxylic acid group provides a polar anchor for conjugation, while the electron-deficient heterocycle enhances electrophilic coupling efficiency. This scaffold exhibits excellent stability under standard bench conditions and serves as a key intermediate in the synthesis of bioactive heterocycles.
5-Bromo-2-chloro-1,3-thiazole-4-carboxylic acid serves as a versatile building block for the synthesis of biologically active heterocycles and pharmaceutical intermediates. Its orthogonal halogenation pattern enables selective cross-coupling reactions, including Suzuki-Miyaura and Stille couplings, while the carboxylic acid group facilitates derivatization via amide or ester formation. The compound exhibits good bench stability and is compatible with standard purification methods, making it well-suited for iterative synthetic workflows in medicinal chemistry and process development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: