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CS-W001157 4
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2-(3-Cyclopropoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

  • CAS No. 1035690-24-4

  • Cat. No. CS-0135505
  • Purity≥97%
  • MDL No.MFCD16994464

*For research and further manufacturing use only, not for direct human use.

2-(3-Cyclopropoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane|CS-0135505

Structure of 1035690-24-4

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General Information

  • CAS No. 1035690-24-4
  • Cat. No. CS-0135505
  • Purity ≥97%
  • MDL No. MFCD16994464
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₂₁BO₃
  • Molecular Weight 260.14
  • Synonym(s) 3-Cyclopropoxyphenylboronic acid pinacol ester
  • SMILES CC1(C)C(C)(C)OB(C2=CC=CC(OC3CC3)=C2)O1

Description

This boronate ester integrates a cyclopropoxy-substituted phenyl moiety with a stable tetramethyl-1,3,2-dioxaborolane scaffold. The electron-rich aryl group enables efficient cross-coupling under standard conditions, while the steric protection enhances shelf stability and moisture tolerance. Ideal for Suzuki-Miyaura reactions in complex molecule synthesis.

Application

2-(3-Cyclopropoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane serves as a stable, bench-ready boronate building block for Suzuki-Miyaura cross-coupling reactions. Its cyclopropoxy-substituted aryl group enables efficient C–C bond formation under standard catalytic conditions, with excellent functional group tolerance and predictable regiochemistry. The tetramethyl substituents enhance stability and solubility, facilitating purification and handling in multi-step synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   27.69
  • LogP   2.527
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   3

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